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Remarkably, while dopaminergic VTA neurons have been extensively studied in the context of food reward and obesity, their ablation has little overall effect on food intake and body weight [164]

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Clinical trials demonstrated average weight loss of 12 to 15 percent of body weight over 68 weeks at maintenance doses

18 They found that patients taking semaglutide were more likely to develop NAION at two, three and four years after initiation of treatment, with a cumulative HR of 2.22 after four years compared to control (n=45 vs 29)

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